DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Anna Paola Pinna; Gabriella Locci; Maria Furno; Daniela Fanni; Gavino Faa; Anna Maria Nurchi

doi:10.7363/020114

Vol. 2 No. 1 (2013), Articles

Vol. 2 No. 1 (2013)

DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Articles

https://doi.org/10.7363/020114

Published 2013-04-04

Anna Paola Pinna⁺⁻
Gabriella Locci⁺⁻
Maria Furno⁺⁻
Daniela Fanni⁺⁻
Gavino Faa⁺⁻
Anna Maria Nurchi⁺⁻

Anna Paola Pinna

Department of Pediatrics and Clinical Medicine, AOU and University of Cagliari

Gabriella Locci

Department of Pathology, AOU and University of Cagliari

Maria Furno

Department of Pediatrics and Clinical Medicine, AOU and University of Cagliari

Daniela Fanni

Department of Pathology, AOU and University of Cagliari

Gavino Faa

Department of Pathology, AOU and University of Cagliari

Anna Maria Nurchi

Department of Pediatrics and Clinical Medicine, AOU and University of Cagliari

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Keywords

DILI
infant
phenobarbital
CYP3A4

How to Cite

Pinna, A. P., Locci, G., Furno, M., Fanni, D., Faa, G., & Nurchi, A. M. (2013). DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM), 2(1), 93-95. https://doi.org/10.7363/020114

Abstract

Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver failure). We describe a case of DILI in a 9-month-old infant caused by chronic therapy with phenobarbital.

https://doi.org/10.7363/020114

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DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

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