Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)

Saliva and fetal life

Jörgen Ekström — 2025-02-28

In humans, Textbooks usually highlight the important roles of saliva in chewing and swallowing, contribution of digestive enzymes and taste, protection and healing of the oral cavity, and speech. However, in the present review by Cabras and colleagues (published in this issue), using non-invasive collection of saliva, the reader is brought into a new unexplored territory for salivary research in humans: the composition of saliva of preterm newborns and the potential functions of saliva and salivary glands during fetal development – is there, for instance, a trophic role for saliva to play?

The use of saliva in clinical practice, with its non-invasive technique, makes great promise of a wide area of applications for diagnostic and prognostic purposes, a major prerequisite for progress and success being, however, solid knowledge in the biochemistry of saliva. A steady flow of well-written, outstanding salivary proteomic studies has emerged over the years from the Cagliari-Rome team, and continues to do so. This review summarizes a gigantic analytic work over more than two decades using top-modern equipment and illustrates how today the coordination of various research groups on a common topic can generate significant progress aimed at characterizing the molecular events underlying human life.

The characterization of preterm newborn saliva by top-down proteomic as a stimulus for the study of human development. A review of the results obtained over the past 25 years

Tiziana Cabras — 2025-02-27

Around the first years of 2000, our teams, at the Cagliari and Catholic-Policlinico Gemelli (Rome) Universities, started an investigation of the intact proteins of human saliva by a top-down pipeline. Since one of the most interesting topics of our research was the study of molecular events occurring during fetal development, we carried out the top-down proteomic analysis on whole saliva of human preterm newborns, induced by the non-invasive specimen collection. The results obtained showed a proteome profile of human preterm newborns sensibly different from that of adults, and they were a stimulus for the study of the variation of several proteins during development, with the support of immunohistochemical methods on tissues obtained at autopsy. This review describes the main results obtained over around 25 years of research. The results on the main protein families of adult saliva, i.e., acidic, basic, and glycosylated proline-rich proteins, amylase, histatins, statherin, P-B peptide, and salivary cystatins, are described in the first section. The results obtained on the salivary proteome of preterm newborns are then reported. A section was devoted to the description of the great heterogeneity of basic proline-rich proteins and of their variable structure in the salivary evolutionary pathway from Homo Neanderthalensis to Homo Sapiens. The chapter on thymosins β₄ and β₁₀ peptides highlights how the results obtained on saliva from preterm newborns stimulated studies on other fetal organs, the latter suggesting some potential role for these peptides during human development. The small proline-rich proteins, cystatins, and S100 proteins are next described. The studies also showed that some enzymes, i.e., the Fam20C kinase recently characterized by another research group, are almost inactive during the last months of fetal development, while other enzymes, i.e., various proteinases and convertases, are much more active in the last fetal period of development than in adults.

Footballomics: urinary metabolomics in adolescents and athletes playing football (soccer) – Review of the literature and practical approach

Vassilios Fanos — 2025-02-13

Sportomics constitutes a true “athlete’s biological passport” for the systematic study of sport-induced responses and adaptations at any biological level. Specifically, metabolomics is a powerful investigative technology that allows the study of changes in an individual’s metabolome in real time, whether under physiological or pathological conditions and/or as a result of individual exposure to epigenetic factors such as environment, diet, and drug use. The specific subject of this contribution is metabolomics applied to football (soccer), which we call “footballomics”. In particular, metabolomics has the potential to provide new information and insights into the complex biological mechanisms that contribute to sports injuries and identify new targets for intervention.

The purpose of this review is to focus on the 12 studies of urinary metabolomics in football players in both adolescence (n = 3) and adulthood (n = 9, of which 1 included adolescents) in order to identify a panel of urinary metabolites useful in practice to prevent injury, monitor functional recovery after fatigue, and optimize athletic training and sports performance.

A practical table suggests important metabolites increased or decreased in urine (and other biofluids) specific to football players (acylcarnitine, alanine, citric acid, 2- and 3-hydroxybutyric acid, 5-hydroxytryptophan, guanidoacetic acid, hypoxanthine, hippurate, lactate, methylhistidine, trimethylamine-N-oxide), that can help in monitoring fatigue and recovery, prevent injuries, optimize performance.

Important elements to consider are: baseline value of metabolites, changes over time (e.g., weekly), changes before and after game, changes during the season, abrupt changes in concentration, correlations with Global Positioning System (GPS) and subjective Rating of Perceived Exertion (RPE), relationship with diet, relationship with any supplement, overall metabolite picture, anticipation of injury and/or illness.

It is not difficult to foresee a bright future for metabolomics in the world of football.

The virtual kidnapping of youth by social media advertising

Marie Leiner — 2024-12-11

The scholarly discourse presented in this document meticulously dissects the intricate phenomenon of “virtual kidnapping” orchestrated by social media advertising. Adolescents are metaphorically ensnared in the digital realm, distanced from genuine interactions and caught in a web of detrimental consequences spanning their mental well-being, social integration, and cognitive development. The evolution of media influence from conventional platforms to the digital domain has heralded a transformative shift toward tailored content dissemination, algorithmic advertising methodologies, and ethical dilemmas surrounding the delineation between manipulation and persuasion in targeting susceptible youth. This article expounds on the deleterious effects of excessive television and social media exposure on young individuals, accentuating its disruptions of sleep patterns, cognitive abilities, physical health, academic attainment, and interpersonal skills. The comparative analysis of marketing practices in television versus social media unveils regulatory disparities and challenges in shielding minors from precision-targeted marketing tactics prevalent in the digital sphere. Moreover, the profound impact of social media on adolescent mental health is rigorously scrutinized, attributing escalating rates of psychological distress, anxiety disorders, and suicidal behavior to constant digital connectivity, pervasive comparison culture, and exposure to unattainable body standards. This discourse underscores the need for heightened awareness, robust regulatory frameworks, and conscientious media consumption practices to fortify the comprehensive well-being of young individuals amidst the burgeoning digital landscape, advocating for a holistic reassessment of media’s pivotal role in shaping youth development.

A “model” as a model: Fabio Mancini European School Project [Article in English and Italian] • [Un “modello” come modello: Fabio Mancini European School Project] [Article in English and Italian]

Fabio Mancini — 2024-12-02

ENGLISH TEXT

Introduction and state of the art: Adolescence is an age characterized – as is well known – by sudden changes at the physical and psycho-cognitive levels, in which adolescents go through complex phases in which affective, emotional and especially social-relational difficulties are intertwined. The most recent orientations in developmental psychology, however, have shifted the focus of the approach to this fundamental phase of development, hitherto framed in the “critical” perspective of difficulties and stress to overcome. By adopting the paradigm of positive psychology, attention can be focused on good practices functional to the promotion of individual well-being, through training that starts from the acquisition of greater self-awareness and the potential to be implemented in order to achieve one’s own well-being (psychological well-being) and, therefore, “happiness”, a term used here net of the legitimate questions that such a complex state of mind poses in order to its very precise definition. Even in the ministerial guidelines of education in several European countries, including Italy, there is now a reversal of the previous promotion of a digital school and e-learning model, pointing to a general reduction in the use of electronic devices (PCs, tablets and cell phones) for educational purposes, in favor of more traditional forms and environments of learning, centered on cooperative learning and social learning.

Project goals: The purpose of the project is to monitor and evaluate the psychological well-being of students, as well as the usefulness of the impact, for this purpose, of the mediation of a communicative model based on direct relationship with a public figure in the school context. Regarding the first point, it is intended to administer, adapting it appropriately, the Oxford Happiness Questionnaire (OHQ), an instrument used to detect the degree of happiness and subjective well-being of individuals. In the implementation of monitoring and of useful interventions in the pursuit of adolescents’ well-being within the educational context, it is believed that a key and innovative role can be played by the active participation in the project of a reference figure for young people, such as a person from outside the school world, with his own successful human and professional educational experience, who offers young people a positive model of dialogue and direct confrontation. The goal is to complement and enrich the socio-affective interaction with adolescents with concrete and direct human input, not mediated by social media. In this direction, the testimony of one of the most sought-after and established international supermodels, known as a “beauty ambassador with a human side,” engaged in volunteer work, philanthropic activities and collaborative projects in various school contexts and in pediatric long-term care wards, can help foster dialogue with adolescents and the exchange of experiences, expectations and ideas useful in overcoming those critical factors that hinder the well-being and serenity of adolescents, especially in contexts of social marginality and educational poverty.

Type of intervention, materials and methods: The beneficiaries of the project are preadolescents and adolescents, and the planned interventions are implemented within schools, as places not only of curricular education, but understood as primary places of community life, socialization and protection of the health and mental and physical well-being of adolescents. The project involves the administration of the OHQ appropriately adapted to students in Italian schools participating in the Adolescent Well-Being School Project. The objective of this questionnaire is to measure happiness in general, that is, psychological well-being. If the OHQ can now boast of an effective use proven by a large number of studies in numerous countries, including non-European ones, the novelty of the present proposal consists mainly in the innovation of the administration context, through a different communicative model, which, playing intentionally with the term that gives the project its title, can also be represented by a supermodel in the role of mediator and facilitator of some phases of the action itself. This choice, as well as being original, is deliberately antithetical to the current trend, which privileges, especially in operations of this type and, more generally, in the context of the daily lives of adolescents, virtual and media relationships, with all the risks of socio-relational deprivation that have already been mentioned and which are, moreover, before everyone’s eyes. The choice therefore falls on a mediating figure who can at the same time offer a concrete and evident testimony to a state of well-being that is also physical, insofar as it comes from a healthy lifestyle, in which, of course, care for nutrition and regular exercise practiced without excesses are included.

Expected results: The ultimate goal is the diffusion and dissemination, among adolescents, of good practices of real and direct, healthy and constructive relationships, both in the peer relationship and in the relationship with family, educational institutions and society. The perspective is to provide support for the development and maturation, as early as adolescence, of skills and attitudes for the construction and maintenance of ongoing individual well-being, a perspective where the individual and autonomous propensity for lifelong learning is also complemented by the fundamental one for lifelong well-being.

ITALIAN TEXT

Introduzione e stato dell’arte: L’adolescenza è un’età caratterizzata – come è noto – da repentini cambiamenti a livello fisico e psico-cognitivo, in cui i ragazzi attraversano fasi complesse nelle quali s’intrecciano difficoltà affettive, emotive e soprattutto socio-relazionali. I più recenti orientamenti della psicologia dell’età evolutiva hanno però spostato il focus dell’approccio a questa fase fondamentale dello sviluppo, finora inquadrata nella prospettiva “critica” delle difficoltà e dello stress da superare. Adottando il paradigma della positive psychology, l’attenzione può essere puntata su buone prassi funzionali alla promozione del benessere individuale, attraverso un training che parte dall’acquisizione di una maggiore consapevolezza di sé e delle potenzialità da attuare al fine del raggiungimento del proprio benessere (psychological well-being) e, quindi, della “felicità”, termine adoperato qui al netto delle legittime questioni che uno stato dell’animo così complesso pone in ordine a una sua definizione ben precisa. Anche negli orientamenti ministeriali dell’istruzione in diversi paesi europei, compresa l’Italia, si assiste oggi a un’inversione di tendenza rispetto alla precedente promozione di un modello di scuola digitale e di e-learning, puntando a una riduzione generale dell’impiego dei dispositivi elettronici (pc, tablet e cellulari) a fini didattici, a favore di forme e ambienti di apprendimento più tradizionali, incentrati sul cooperative learning e l’apprendimento sociale.

Obiettivi del progetto: Scopo del progetto è monitorare e valutare il benessere psicologico degli studenti, nonché l’utilità dell’impatto, a tal fine, della mediazione di un modello comunicativo fondato sulla relazione diretta con un personaggio pubblico nel contesto scolastico. Per quanto concerne il primo punto, s’intende somministrare, adattandolo opportunamente, l’Oxford Happiness Questionnaire (OHQ), strumento utilizzato per rilevare il grado di felicità e benessere soggettivo degli individui. Nell’attuazione del monitoraggio e di interventi utili al perseguimento del benessere degli adolescenti nell’ambito del contesto formativo, si ritiene che possa svolgere un ruolo chiave e innovativo la partecipazione attiva al progetto di una figura di riferimento per i giovani, quale può considerarsi un soggetto esterno al mondo della scuola, con una propria esperienza formativa umana e professionale di successo, che offra ai ragazzi un modello positivo di dialogo e confronto diretto. L’obiettivo è quello di integrare e arricchire l’interazione socioaffettiva con gli adolescenti di un apporto umano concreto e diretto, non mediato dai social media. In tale direzione, la testimonianza di un top model fra i più ricercati e affermati a livello internazionale, noto come “beauty ambassador dal lato umano”, impegnato nell’ambito del volontariato, in attività filantropiche e in progetti di collaborazione in diversi contesti scolastici e nei reparti pediatrici di lungodegenza, può contribuire a favorire il dialogo con gli adolescenti e lo scambio di esperienze, aspettative e idee utili al superamento di quei fattori di criticità che ostano al benessere e alla serenità degli adolescenti, soprattutto in contesti di marginalità sociale e di povertà educativa.

Tipologia d’intervento, materiali e metodi: I soggetti beneficiari del progetto sono i preadolescenti e gli adolescenti, e gli interventi previsti sono attuati all’interno delle scuole, quali presidi non solo della formazione curricolare, ma intese come luoghi primari di vita comunitaria, di socializzazione e di tutela della salute e del benessere psico-fisico degli adolescenti. Il progetto prevede la somministrazione dell’OHQ opportunamente adattato agli studenti delle scuole italiane che aderiscono all’Adolescent Well-Being School Project. L’obiettivo di questo questionario è misurare la felicità in generale, cioè il benessere psicologico. Se l’OHQ può vantare ormai un impiego efficace e comprovato da una nutrita serie di studi in numerosi paesi anche extra-europei, la novità della presente proposta consiste principalmente nell’innovazione del contesto di somministrazione, attraverso un diverso modello comunicativo, che, giocando volutamente con il termine che dà il titolo al progetto, può essere rappresentato anche da un top model in veste di mediatore e facilitatore di alcune fasi dell’azione stessa. Tale scelta, oltre che originale, è volutamente antitetica all’attuale tendenza, che privilegia, soprattutto in operazioni di questo tipo e, più in generale, nel contesto della vita quotidiana degli adolescenti, le relazioni virtuali e mediatiche, con tutti i rischi di deprivazioni socio-relazionali cui si è già accennato e che sono, del resto, sotto gli occhi di tutti. La scelta ricade perciò su una figura di mediazione che possa al tempo stesso offrire una testimonianza concreta ed evidente di uno stato di benessere che è anche fisico, in quanto riveniente da un regime di vita sano, in cui naturalmente rientrano la cura dell’alimentazione e un esercizio fisico regolare e praticato senza eccessi.

Risultati attesi: L’obiettivo finale è la diffusione e disseminazione, fra gli adolescenti, di buone prassi di relazioni reali e dirette, sane e costruttive, sia nel rapporto tra pari sia nel rapporto con la famiglia, le istituzioni formative e la società. La prospettiva è quella di fornire un supporto allo sviluppo e alla maturazione, sin dall’adolescenza, di capacità e attitudini alla costruzione e al mantenimento di un benessere individuale costante, una prospettiva che alla propensione individuale e autonoma al lifelong learning affianchi anche quella imprescindibile al lifelong well-being.

Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024

--- Various Authors — 2025-01-20

Selected Abstracts of the 20^th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23^rd-26^th, 2024

CHILDREN’S HEALTH: MESSAGES FROM THE FUTURE

The Workshop has been organized with the patronage of Autonomous Region of Sardinia, City of Cagliari, Azienda Ospedaliera di Cagliari, University of Cagliari, Board of Physicians of the Province of Cagliari, Italian-Albanian Pediatric Society, AMBO (Alleanza per un Ambiente a misura di Bambino: alliance for a child-friendly environment), European Project Better4u, European Project Life Milch, National Confederation of Pediatrics Heads (CONAPP), Italian Federation of Family Pediatricians (FIMP), Italian-Arabian Pediatric Society (IAPS), Italian-Romanian Pediatric Society (IRPS), Norman Group of Neonatal and Pediatric Nephrology, International Academy of Perinatal Medicine, Italian Society of Pediatric Allergology and Immunology (SIAIP), Italian Society of Clinical Biochemistry (SIBioC), Italian Society of Gynecology of Infancy and Adolescence (SIGIA), Italian Society of Neonatology (SIN), Italian Society of Hospital Pediatricians (SIPO), Association SIPO in the World, Italian Society of Developmental Origins of Health and Disease (SI-DOHaD), Alfred Nobel International Study Center Sanremo, Italian Society of Pediatricians (SIMPE), Italian Society of Pediatric Psychology (S.I.P.Ped.), Romanian Society of Pediatrics, Italian Society for Research on Essential Oils (SIROE), Italian Society of Neonatal Nursing (SIN INF), Union of European Neonatal and Perinatal Societies (UENPS).

ABS 1. EXAMINATION OF CBD PRODUCT SAFETY MESSAGING FOR CHILDREN IN SOCIAL MEDIA PLATFORMS: A COMPARATIVE STUDY • I. Ham, O.S. Khilji, M. Leiner (El Paso, Texas, USA)

ABS 2. L1CAM IS SECRETED THROUGH EXOSOMES IN THE DEVELOPING HUMAN BRAIN • F. Cau, F. Coghe, G. Faa (Cagliari, Italy; Philadelphia, Pennsylvania, USA)

ABS 3. LANGUAGE DEFICIENCIES IN CHILDHOOD – INTERDISCIPLINARY APPROACHES • S.L. Burlea, G. Burlea, V.V. Lupu (Iași, Romania)

ABS 4. LONG-TERM EFFECTS OF EARLY VOCAL CONTACT, BY PARENTS’ BOOK-READING, FOR PRETERM NEWBORNS IN NICUs • C. Peila, S. Deantoni, L. Riboldi, M. Mainardi, E. Bertino, A. Coscia (Turin, Italy)

ABS 5. RESPIRATORY DISTRESS IN A FEMALE INFANT WITH PRIMARY CILIARY DYSKINESIA. A CASE REPORT • E. Tsianaka, M. Karypidou, A. Loutsidi, K. Angelou, A. Charitou (Athens, Greece)

ABS 6. WHEN CLINICAL FINDINGS REVEAL THE DIAGNOSIS: A CASE OF WILLIAMS SYNDROME • E. Esposito, G. Sanna, F. Comisi, M. Marica, S. Savasta (Cagliari, Italy)

ABS 7. NON-FATAL DROWNING: A CASE REPORT • V. Carosio, C. Cocco, R. Basile, G. Cherchi (Cagliari, Italy)

ABS 8. CLEIDOCRANIAL DYSPLASIA • B.M. Trapani (Sion, Switzerland)

ABS 9. PANAYIOTOPOULOS SYNDROME: A CASE REPORT • L. Calandriello, V. Ferasin, S. Bellonzi, L. Dell’Anna, C. Lorenzetto, F. Marino, G. Passarella, F. Rigon, E. Fiumana, A. Mussari, L. Saggioro, F. Sansone, S. Rugolotto (Rovigo, Padua and Verona, Italy)

ABS 10. MEASURING KNOWLEDGE OF PARENTS AND CHILDREN WITH CONGENITAL HEART DISEASE: ADAPTATION AND VALIDATION OF THE “LEUVEN KNOWLEDGE QUESTIONNAIRE FOR CONGENITAL HEART DISEASE” • S. Flocco, F. Crò, C. Arrigoni, G. Conte, G. Zaffino, S. De Vecchi, L. Schianchi, G. Campioni, M. Chessa, R. Caruso, A. Magon (Milan and Pavia, Italy)

ABS 11. NEW PERSPECTIVES ON NEONATAL LUNG ASSESSMENT • S. Carnazzo, S. Nasikas, F.F. Comisi (Catania, Italy; Paris, France)

ABS 12. THE ODYSSEY OF CHRONIC PAIN • G. Sanna, F.F. Comisi, E. Esposito, C. Soddu, S. Savasta (Cagliari, Italy)

ABS 13. PROPHYLAXIS IN CHILDHOOD IN THE REPUBLIC OF BULGARIA • T. Itova (Ruse, Bulgaria)

ABS 14. LYSOZYME IS HIGHLY EXPRESSED IN MATERNAL MILK STEM/PROGENITOR CELLS • G. Faa, G. Pichiri, P. Coni, M. Piras, Y. Gibo, A. Reali, V. Fanos (Cagliari, Italy; Philadelphia, Pennsylvania, USA; Matsumoto, Japan)

ABS 15. TRIMETHYLAMINURIA • B.M. Trapani (Sion, Switzerland)

ABS 16. STEVENS-JOHNSON SYNDROME IN CHILDHOOD: TWO CASE REPORTS • F. Marino, L. Dell’Anna, V. Ferasin, F. Rigon, S. Bellonzi, L. Calandriello, F. Sansone, C. Lorenzetto, E. Fiumana, G. Passarella, A. Mussari, L. Saggioro, S. Rugolotto (Rovigo, Padua and Verona, Italy)

ABS 17. KAWASAKI DISEASE OR MIS-C? • S. Vendemmia, I. Pezone, M. Vendemmia (Aversa and Naples, Italy)

ABS 18. RISK FACTORS FOR RECOARCTATION OF THE AORTA AFTER SURGICAL REPAIR IN PEDIATRIC PATIENTS • G. Concas, E. Esposito, A. Atzei, P. Neroni, A. Giamberti, M. Chessa, V. Fanos (Cagliari and Milan, Italy)

ABS 19. PRIMARY LYMPHEDEMA: TWO CASE REPORTS IN CHILDREN • L. Dell’Anna, F. Marino, F. Rigon, S. Bellonzi, E. Fiumana, L. Calandriello, F. Sansone, C. Lorenzetto, G. Passarella, V. Ferasin, L. Saggioro, A. Mussari, C. Bertolin, S. Rugolotto (Padua, Rovigo and Verona, Italy)

ABS 20. A COMMON PRESENTATION, YET A RARE DIAGNOSIS: INSIGHTS INTO MRFACD SYNDROME • F.F. Comisi, E. Esposito, G. Sanna, M. Marica, C. Soddu, S. Savasta (Cagliari, Italy)

ABS 21. ADMINISTERING DRUGS IN NEONATAL POPULATION THROUGH IN-LINE FILTERS: RESULTS OF FILTERABILITY STUDIES • C. Capetti, E. Maggiora, M. Capitanio, S. Deantoni, C. Quarti, C.G. Catona, F. De Matteis, S. Cosimi, M. Luciano, E. Bertino, A. Coscia, F. Cresi (Turin and Milan, Italy)

ABS 22. A RETROSPECTIVE ANALYSIS OF UPJO CLINICAL BURDEN IN SARDINIAN CHILDREN • A. Bertini, M. Cossu, M.E. Murru, M. Gamberoni, V. Manca, E. Flore, F. Zurrida, G. Masnata (Cagliari, Italy)

ABS 23. CLINICAL VARIABILITY IN SSADHD • M. Gamberoni, C. Sbaffi, G. Sanna, M. Asunis, M. Balzarini, E. Flore, D. Pruna, G. Masnata (Cagliari, Italy)

ABS 24. AN UNSUPERVISED LEARNING TOOL FOR STEM CELL BURDEN ASSESSMENT IN THE PRETERM KIDNEY • M. Fraschini, V. Fanos, L. Didaci, G. Faa (Cagliari, Italy; Philadelphia, Pennsylvania, USA)

ABS 25. MOVEMENT-DEPENDENT MODULATION OF MULTISENSORY INTEGRATION EARLY IN LIFE: THE DEVELOPMENTAL CONTEXT OF A SPATIAL BODILY-SELF REPRESENTATION • C. Peila, S. Deantoni, L. Riboldi, G. Serra, A. Rossi Sebastiano, I. Ronga, K. Poles, S. Russo, A. Comanducci, A. Coscia, E. Bertino, A. Pigorini, F. Garbarini (Turin and Milan, Italy)

ABS 26. BASIC FAMILY-CENTERED CESAREAN SECTION OUTCOMES: A RETROSPECTIVE COHORT STUDY • L. Saggioro, F. Marino, L. Dell’Anna, V. Ferasin, F. Rigon, S. Bellonzi, L. Calandriello, F. Sansone, C. Lorenzetto, E. Fiumana, G. Passarella, A. Mussari, S. Rugolotto (Verona, Rovigo and Padua, Italy)

ABS 27. FEBRILE SEIZURES AS A MANIFESTATION OF ENCEPHALITIS • M. Cossu, M. Olla, A. Falchi, A. Ghigino, A. Bertini, S. Cossu, D. Pruna, B. Cancedda, M. Tiddia, G. Masnata, M. Zanda (Cagliari, Italy)

ABS 28. ASSESSING EARLY PREDICTORS OF 12-MONTH NEURODEVELOPMENT IN INFANTS WITH CONGENITAL CMV: A SINGLE-CENTER EXPERIENCE • C. Deantoni, A. Spadavecchia, C. Rubino, A. Leone, C. Terzi, C. Angieri, E. Maggiora, C. Peila, E. Bertino, F. Cresi, A. Coscia (Turin, Italy)

ABS 29. CASE REPORT: INFANT WITH PNEUMOCOCCAL MENINGITIS AND SEPSIS • A. Falchi, A. Ghigino, V. Sanneris, C. Sbaffi, D. Manunza, D. Congiu, G. Masnata, M. Zanda (Cagliari, Italy)

ABS 30. UNMASKING THE OVERLOOKED: RECOGNIZING BEALS-HECHT SYNDROME • G. Sanna, E. Esposito, F.F. Comisi, C. Soddu, S. Savasta (Cagliari, Italy)

ABS 31. RENAL INVOLVEMENT IN TWO PEDIATRIC CASES OF SEPSIS • F. Zanco, V. Sanneris, M. Cossu, M. Olla, F. Zurrida, V. Manca, M. Balzarini, L. Foschini, M. Zanda, G. Masnata (Cagliari, Italy)

ABS 32. BASSEL-HAGEN DISEASE AND ARTHRALGIA: IS THE EXT GENE TO BLAME? • F.F. Comisi, C. Cerruto, E. Esposito, G. Sanna, S. Carnazzo, S. Savasta, R. Mura (Cagliari, Vittoria and Catania, Italy)

ABS 33. A CAT-ASTROPHIC CASE OF FUO! • E. Esposito, F. Comisi, G. Sanna, S. Campus, S. Savasta (Cagliari, Italy)

ABS 34. NON-OBSTETRIC SURGERY DURING PREGNANCY: A CASE REPORT AND A NEONATOLOGY PERSPECTIVE • V. Ferasin, S. Bellonzi, L. Calandriello, L. Dell’Anna, C. Lorenzetto, F. Marino, G. Passarella, F. Rigon, E. Fiumana, A. Mussari, L. Saggioro, F. Sansone, S. Rugolotto (Padua and Rovigo, Italy)

ABS 35. BODY DYSMORPHIC DISORDER: SOCIAL MEDIA IMPACT • S. Petza (Cagliari, Italy)

ABS 36. BROWN RECLUSE SPIDER BITE IN CHILDREN: A CASE REPORT • M. Rossi, G. Pianese, M.R. Angelo, G. Cherchi (Cagliari, Italy)

ABS 37. NIGHT AND DAY URINARY INCONTINENCE • A. Bertini, M. Cossu, M. Gamberoni, V. Manca, E. Flore, F. Zurrida, G. Masnata (Cagliari, Italy)

ABS 38. SEGMENTAL PIK3CA-RELATED OVERGROWTH SYNDROME: DIAGNOSIS AND NEW THERAPEUTIC STRATEGIES • C. Sbaffi, M. Gamberoni, M. Manca, E. Flore, V. Setzu, S. Murru, M. Balzarini, G. Masnata (Cagliari, Italy)

ABS 39. MISSING A PINCH OF SALT IN A NEONATE • F. Sansone, V. Ferasin, S. Bellonzi, L. Dell’Anna, C. Lorenzetto, F. Marino, G. Passarella, F. Rigon, E. Fiumana, A. Mussari, L. Saggioro, L. Calandriello, S. Rugolotto (Rovigo, Padua and Verona, Italy)

ABS 40. SYDENHAM’S CHOREA: CORTICOSTEROIDS’ ROLE IN QUICK SYMPTOM CONTROL • M. Manca, G. Sanna, F. Zanco, V. Sanneris, S. Cossu, S. Dettori, D. Pruna, E. Flore, C. Angioni, S. Marras, M. Zanda, G. Masnata (Cagliari, Italy)

ABS 41. A NEW CHALLENGE: BITTER TASTE RECEPTORS • B.M. Trapani, G. Trapani (Sion, Switzerland; Sanremo, Italy)

ABS 42. FETAL AND NEONATAL ARRYTHMIAS: PERSONAL EXPERIENCE WITH 167 CASES • M.R. Scanu, A. Atzei, P. Neroni, V. Fanos (Cagliari, Italy)

ABS 43. NOT JUST HYPERGLICINEMIA… • I. Rulli, A.M. Carcione, E. Gitto (Messina, Italy)

ABS 44. EXTERNAL CEPHALOHEMATOMA WITH ATYPICAL CLINICAL COURSE • A. D’Apuzzo, M. Vendemmia (Naples, Italy)

ABS 45. ATP: A POTENTIAL WEAPON AGAINST HCAI IN THE NICU • G. Simoni, M. Melis, V. Fanos (Cagliari, Italy)

ABS 46. MAGNET INGESTION IN CHILDREN: A CASE REPORT • M. Marsan, M. Brutti, R. Cacace, G. Amato, F. Sau, G. Cherchi (Cagliari, Italy)

ABS 47. INTERNATIONAL STANDARDS FOR TWIN NEWBORN WEIGHT, LENGTH, AND HEAD CIRCUMFERENCE BY GESTATIONAL AGE AND SEX: THE INTERGROWTH-21^ST CROSS-SECTIONAL STUDY • F. Giuliani, S. Deantoni, S. Gandino, A. Coscia, I. Stura, S.H. Kennedy, A.T. Papageorghiou, E. Bertino, G. Migliaretti, J. Villar for the International Fetal and Newborn Growth Consortium (INTERGROWTH-21^st) (Turin, Italy; Oxford, UK)

ABS 48. ACUTE LYMPHOBLASTIC LEUKEMIA AND GANGLIONEUROBLASTOMA: CASE REPORT • F. Gigliotti, C. Fortugno, E. Galea, R. Cantaffa, D. Loiacono, V. Talarico, M. Ceravolo, A. Pugliese, G. Raiola, M.C. Galati (Catanzaro, Italy)

ABS 49. ANTITUMOR ACTIVITY OF LAROTRECTINIB IN GLIOBLASTOMA MULTIFORME WITH NTRK GENE AMPLIFICATION CASE REPORT • F. Gigliotti, C. Fortugno, E. Galea, R. Cantaffa, R.L. Fabiano, V. Talarico, M. Ceravolo, G. Raiola, M.C. Galati (Catanzaro, Italy)

ABS 50. ABERNETHY TYPE II MALFORMATION IN CHILDREN: AN UNUSUAL PRESENTATION. A CASE OF ABERNETHY MALFORMATION • V. Talarico, A. Nicoletti, G. Guarascio, A. Viscomi, G. Stranieri, A. Gigliotti, M.C. Galati, D. Alberti, G. Raiola (Catanzaro and Brescia, Italy)

ABS 51. A STUDY OF CORD BLOOD ALKALINE PHOSPHATASE AS A PREDICTOR OF NEONATAL HYPERBILIRUBINEMIA IN A TERTIARY HOSPITAL • V.B. Sonawane, R. Agarwal, M. Maksud, A. Saxena, V. Kotrashetti (Nerul, Maharashtra, India)

ABS 52. PERCEIVED FAMILY FUNCTION, PERCEIVED SOCIAL SUPPORT AND DEPRESSION OF NEW PARENTS UNDER COVID-19 PANDEMIC: A DYADIC ANALYSIS • T. Kokkinaki, K. Koutra, O. Michopoulou, L. Chaziraki, P. Kokarida, E. Hatzidaki (Rethymnon, Heraklion and Chania, Greece)

ABS 53. EVALUATING THE PREVALENCE OF POSTNATAL GROWTH FALTERING OF PRETERM INFANTS USING TWO GROWTH CHARTS AND ITS RELATION TO CLINICAL AND NUTRITIONAL PARAMETERS • I. Kakatsaki, N. Anagnostatou, T. Roumeliotaki, S. Papanikolaou, E. Hatzidaki (Heraklion, Greece)

Selected Abstracts of the 8th World Summit on Pediatrics; Madrid (Spain); October 3-6, 2024

--- Various Authors — 2025-01-29

Selected Abstracts of the 8^th World Summit on Pediatrics

"Advances in Pediatrics in Technology, Mental Health, Child Disparities, Nutrition, and Immunization Strategies"

Madrid (Spain) • October 3^rd-6^th, 2024

The Summit has been organized with the Scientific Support of SIMPE (Italian Society of Pediatric Physicians, Società Italiana Medici Pediatri); Department of Pediatrics, Foster School of Medicine, TTUHSC El Paso (Texas Tech University Health Sciences Center El Paso); UTEP (The University of Texas at El Paso); Staten Island University Hospital, Northwell Health; UACJ (Autonomous University of Ciudad Juárez, Universidad Autónoma de Ciudad Juárez).

ABS 1. ABSTRACTS PRESENTATION FOR THE 8TH WORLD SUMMIT ON PEDIATRICS • G. Trapani (Sanremo, Italy)

ABS 2. LEVELS OF DEPRESSION AND ANXIETY AMONG STUDENTS OF LEYTE NATIONAL HIGH SCHOOL AFTER REOPENING OF IN-PERSON CLASSES • J.P. Cadion, K.F. San Gabriel, A.E. Lim Jr. (Tacloban City, Philippines)

ABS 3. WHEN A FUNCTIONAL NEUROLOGIC DISORDER OVERLAPS WITH AN UNCOMMON ADVERSE DRUG REACTION: A CHALLENGING DIAGNOSIS • M. Proserpio, S. Darteyre (Lausanne, Switzerland)

ABS 4. ACCESS TO SERVICES, QUALITY OF CARE AND QUALITY OF LIFE FOR CHILDREN WITH AUTISM SPECTRUM DISORDER: A CROSS-SECTIONAL STUDY FROM CAREGIVERS’ PERSPECTIVE • M. Jakubauskiene, R. Perminaite, J. Petrulyte (Vilnius and Kaunas, Lithuania)

ABS 5. RECURRENT WHEEZING IN YOUNG CHILDREN: RISK FACTORS AND PREDICTION • A. Mkhitaryan, K. Simonyan (Yerevan, Armenia)

ABS 6. RIGHT PULMONARY ARTERY ORIGINATING FROM ASCENDING AORTA (HEMITRUNCUS ARTERIOSUS) WITH VACTERL ASSOCIATION IN A NEONATE: A CASE REPORT • T. Kim, B.-S. Shin (Yangsan-si, Korea)

ABS 7. LEMIERRE SYNDROME – NO LONGER LOST? • L. Henfrey, C. Devanahalli Nagaraj (Derby, UK)

ABS 8. FROM ADVERSE CHILDHOOD EXPERIENCES TO INFLAMMATION: EXPLORING ITS ASSOCIATION IN MEXICAN CHILDREN • A.J. del Rio, I. Martín del Estal, J. Rodríguez de Ita, D. León Rojas, J. Diaz, F. Castorena-Torres (Monterrey, Mexico)

RETRACTED: The impact of climate change on pediatric health: a literature review on emerging risks

Kirolos Eskandar — 2024-12-23

RETRACTION NOTE

JPNIM strives to provide original academic content.

On submission of a paper to JPNIM, in the submission form, the authors declare explicitly that their submission is original, i.e. it has not been previously published, nor is it before another journal for consideration. Moreover, before publication, the authors sign a publication agreement containing those declarations.

Unfortunately, the Editors of JPNIM have become aware of the fact that an article with the same title and essentially the same text was published in another journal:

Eskandar K. The Impact of Climate Change on Pediatric Health: A Literature Review on Emerging Risks. Rev Ecuat Pediatr. 2024;25(3):24-36.

For this reason, the Editors of JPNIM have decided to retract the paper due to article duplication.

A separate retraction notice has also been issued: [No Authors listed]. Retraction notice regarding “The impact of climate change on pediatric health: a literature review on emerging risks”. J Pediatr Neonat Individual Med. 2025;14(1):e140116. doi: 10.7363/140116.

---

Climate change represents one of the most significant global health threats of the 21^st century, with children being particularly vulnerable to its effects. This literature review examines the emerging risks posed by climate change on pediatric health, highlighting the multifaceted impacts on respiratory health, heat-related illnesses, vector-borne diseases, nutrition, mental health, and exposure to waterborne pathogens. Additionally, the review explores the disproportionate effects on children from marginalized communities, underscoring the urgent need for targeted interventions and policies. By synthesizing current research, this article aims to raise awareness among healthcare professionals and policymakers about the pressing need to protect pediatric populations from the evolving challenges of climate change.

Retraction notice regarding “The impact of climate change on pediatric health: a literature review on emerging risks”

--- No Authors listed — 2025-03-06

This retraction notice regards the following article:

Eskandar K. RETRACTED: The impact of climate change on pediatric health: a literature review on emerging risks. J Pediatr Neonat Individual Med. 2025;14(1):e140106. doi: 10.7363/140106.

JPNIM strives to provide original academic content.

Unfortunately, the Editors of JPNIM have become aware of the fact that an article with the same title and essentially the same text was published in another journal:

Eskandar K. The Impact of Climate Change on Pediatric Health: A Literature Review on Emerging Risks. Rev Ecuat Pediatr. 2024;25(3):24-36.

For this reason, the Editors of JPNIM have decided to retract the paper due to article duplication.

Symbrachydactyly: a rare congenital anomaly – A case report

Sampath Gnanarathne — 2025-03-10

Introduction: Symbrachydactyly is a rare unilateral congenital hand anomaly with an incidence of approximately 1 in 32,000 babies born each year. It usually presents with shortened or absent central digits, sparing border digits. It can occur following an insult to the apical ectodermal ridge mainly affecting the vascular supply of the upper limb. According to the extent of skeletal involvement of the hand, there are variety of clinical presentations. This paper presents a case of symbrachydactyly involving the right upper limb with absent central digits, highlighting the presentation, classification, etiology, and possibilities of effective management.

Case report: A 38-year-old mother of 2 children presented in her 3rd pregnancy, following an uncomplicated pregnancy period. She was not exposed to any chemicals or radiation during pregnancy. A male neonate was born following an uncomplicated normal vaginal delivery. The neonate was born with absent fingers on the right hand, which were not identified prenatally. He had a normal left hand. The parents were counseled and the baby was referred to a pediatric plastic surgeon after a multidisciplinary meeting.

Conclusion: Symbrachydactyly, despite its rarity, can significantly affect the child’s quality of life. In this case, the neonate had absent middle fingers with two nubbins instead of border digits on the right hand, which can be classified under the peromelic type according to the Blauth classification. Prevention is challenging due to uncertain etiology. The child’s quality of life is limited by the degree of skeletal involvement. Depending on the degree of involvement, surgical or non-surgical methods and rehabilitation can improve the function of the hand.

Subcutaneous fat necrosis of the newborn complicated by severe hypercalcemia and hypertriglyceridemia

Sofien Atitallah — 2025-03-11

Subcutaneous fat necrosis of the newborn (SCFN) is a rare acute hypodermatitis characterized by firm, indurated plaques and subcutaneous nodules with purplish-red color, typically occuring between the 1^st and 6^th weeks of life. While generally benign and self-resolving, this condition can occasionally lead to severe complications.

We report the case of a female newborn with a maternal history of hypothyroidism and severe preeclampsia, and a personal history of perinatal asphyxia and sepsis, admitted on the 20^th day of life for fever and dehydration. Dermatological examination revealed indurated purplish-red nodules on the back and arms. Laboratory tests showed severe hypercalcemia and hypertriglyceridemia, while renal ultrasound revealed nephrocalcinosis. A diagnosis of SCFN, complicated by severe hypercalcemia, hypertriglyceridemia and nephrocalcinosis, was made. The patient was treated with intravenous fluids, diuretics, and corticosteroids, resulting in clinical and biological improvement.

Although SCFN often resolves spontaneously, severe complications like hypercalcemia may require intervention. Early diagnosis and management, particularly in neonates with multiple risk factors, are crucial to prevent complications. Further research is needed to optimize treatment strategies and improve outcomes for affected infants.