Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) <p>The <strong>Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)</strong> is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way.</p> <p>Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.</p> en-US Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2281-0692 <p>© Hygeia Press</p> <p> </p> <h3>Copyright and publishing rights</h3> <p>Regarding copyright, before publication, Authors declare that, in consideration of the action of JPNIM in reviewing and editing their submission, they transfer, assign, or otherwise convey all copyright ownership, including any and all rights incidental thereto, exclusively to the JPNIM Publisher (Hygeia Press di Corridori Marinella).</p> <div> <div> <div> <div> <div> <p>Authors have the opportunity to reuse figures, tables and selected text up to 250 words from their article as finally published, providing that full and accurate credit shall be given to publication in JPNIM and that modifications are noted (otherwise no changes may be made).</p> </div> </div> </div> </div> </div> Selected Abstracts of the 12th International Congress of UENPS; Krakow (Poland); September 2nd-4th, 2022 <p><strong>Selected Abstracts of the 12<sup>th</sup> International Congress of UENPS; Krakow (Poland); September 2<sup>nd</sup>-4<sup>th</sup>, 2022&nbsp;</strong></p> <p>The Congress has been organized by the Union of European Neonatal and Perinatal Societies (UENPS).&nbsp;</p> <p>&nbsp;</p> <p><strong>ABS 1. OUTCOMES OF DIAPHRAGMATIC HERNIA PATIENTS WITH AND WITHOUT FETOSCOPIC ENDOLUMINAL TRACHEAL OCCLUSION (FETO) – A SINGLE-CENTRE RETROSPECTIVE STUDY</strong> •&nbsp;A. Adamiec, A. Nieradka, M. Jaskólska, J. Schreiber-Zamora, B. Kociszewska-Najman (Warsaw, Poland)&nbsp;</p> <p><strong>ABS 2. </strong><strong>PROTECTIVE EFFECTS OF CAPSAICIN ON IBOTENATE-INDUCED NEONATAL EXCI­TOTOXIC BRAIN DAMAGE AND NEURO­INFLAMMATION</strong> • Y. Baranoglu Kilinc, M. Dilek, E. Kilinc, I.E. Torun, A. Saylan, S. Erdogan Duzcu (Bolu, Turkey)&nbsp;</p> <p><strong>ABS 3. </strong><strong>ADJUVANT THERAPY WITH A FRAGMENT OF RECOMBINANT SURFACTANT PROTEIN D IMPROVES LUNG COMPLIANCE AND REDUCES LEVELS OF PRO-INFLAMMATORY CYTOKINES IN VENTILATED PRETERM LAMBS</strong> • R. Bhatt, M. Baroudi, A. Finkielsztein, M. Kemp, B. Kramer, N. Marlow, J. Madsen, H. Clark (London, United Kingdom; Perth, Australia; Maastricht, The Netherlands)&nbsp;</p> <p><strong>ABS 4. </strong><strong>DERMAL BILIRUBIN IN CAUCASIAN NEWBORN INFANTS WITHIN THE FIRST 4 DAYS OF LIFE</strong> • L. Casnocha Lucanova, J. Zibolenova, K. Matasova Jr., K. Matasova, M. Zibolen (Martin, Slovakia)&nbsp;</p> <p><strong>ABS 5. </strong><strong>PREDICTORS OF ABNORMAL NEUROIMAGING RESULTS IN NEWBORNS WITH CONGENITAL CMV INFECTION (cCMV)</strong> •&nbsp;J. Czech-Kowalska, D. Jedlińska-Pijanowska, A. Pleskaczyńska, A. Niezgoda, K. Gradowska, A. Pietrzyk, E. Jurkiewicz, M. Jaworski, B. Kasztelewicz (Warsaw, Poland)&nbsp;</p> <p><strong>ABS 6. </strong><strong>RISK OF NECROTIZING ENTEROCOLITIS AND ENTERAL FEEDING STRATEGY IN THE CHILDREN’S CLINICAL UNIVERSITY HOSPITAL (RIGA, LATVIA) FROM THE 1<sup>ST</sup> OF JANUARY 2016 TO THE 31<sup>ST</sup> OF DECEMBER 2020</strong> • D. Dakica, A. Smildzere (Riga, Latvia)&nbsp;</p> <p><strong>ABS 7. </strong><strong>OUTBREAK OF NOSOCOMIAL SEPSIS IN NICU</strong> <strong>BY MULTIDRUG-RESISTANT </strong><em><strong>KLEBSIELLA PNEUMONIAE</strong></em><strong> – DIAGNOSTIC CHALLENGES</strong> •&nbsp;P. Gatseva, V. Atanasova, S. Porov, Z. Yordanov (Pleven, Bulgaria)&nbsp;</p> <p><strong>ABS 8. </strong><strong>PREDICTIVE MARKERS FOR BRONCHO­PULMONARY DYSPLASIA IN NONINVASIVELY OBTAINED AMNIOTIC FLUID IN PRETERM NEONATES</strong> • V. Gulbiniene, G. Balciuniene, R. Viliene, I. Dumalakiene, I. Pilypiene, D. Ramasauskaite (Vilnius, Lithuania)&nbsp;</p> <p><strong>ABS 9. </strong><strong>PRETERM GESTATION AND LOW BIRTH WEIGHT – IMPACT ON RESPIRATORY SYSTEM</strong> •&nbsp;E. Kandelaki, N. Solomonia, N. Kavlashvili, M. Kherkheulidze (Tbilisi, Georgia)&nbsp;</p> <p><strong>ABS 10. </strong><strong>ASSESSMENT OF PAIN AND DISCOMFORT DURING LESS INVASIVE SURFACTANT ADMINISTRATION (LISA) UNDER NON-PHARMACOLOGICAL ANALGESIA</strong> • K. Klebermaß-Schrehof, K. Pichler, B. Kühne, S. Stummer, A. Berger, A. Kribs, J. Dekker (Vienna, Austria; Cologne, Germany; Leiden, The Netherlands)&nbsp;</p> <p><strong>ABS 11. </strong><strong>A NOVEL POINT-OF-CARE ULTRASOUND APPROACH FOR THE DETERMINATION OF ENDOTRACHEAL TUBE DEPTH IN NEONATES</strong> •&nbsp;O. Levkovitz, D. Schujovitzky, R. Stackievicz, P. Fayoux, I. Morag, I. Litmanovitz, S. Arnon, S. Bauer (Kfar Saba, Zrifin, and Tel Aviv, Israel; Lille, France)&nbsp;</p> <p><strong>ABS 12. </strong><strong>END-OF-LIFE CARE PRACTICES ACROSS POR­TUGUESE NEONATAL UNITS</strong> • C. Liz, E. Proença, C. Carvalho (Porto, Portugal)&nbsp;</p> <p><strong>ABS 13. </strong><em><strong>LIMOSILACTOBACILLUS REUTERI DSM 17938</strong></em><strong> IN THE PREVENTION OF FUNCTIONAL GASTROINTESTINAL DISORDERS IN NEO­NATES TREATED WITH ANTIBIOTICS: A RANDOMIZED CONTROLLED TRIAL</strong> • J. Lozar Krivec, G. Nosan, P. Bratina, P. Nabergoj, A. Valcl, E. Benedik, T. Obermajer, B. Bogovič Matijašić, U. Šetina, A. Mahnič, D. Paro-Panjan (Ljubljana,&nbsp;Postojna, Slovenj Gradec, Domžale, and Maribor, Slovenia)&nbsp;</p> <p><strong>ABS 14. </strong><strong>ANTENATAL STEROID TREATMENT AND BRAIN DEVELOPMENT IN VLBW INFANTS</strong> • M. Malova, A. Parodi, P. Massirio, D. Minghetti, M. Severino, D. Tortora, C. Traggiai, D. Preiti, S. Uccella, L. Nobili, A. Rossi, L.A. Ramenghi (Genoa, Italy)&nbsp;</p> <p><strong>ABS 15. </strong><strong>FACTORS AFFECTING THE DURATION OF MECHANICAL VENTILATION IN VERY LOW BIRTH WEIGHT INFANTS</strong> • A. Menshykova, D. Dobryanskyy (Lviv, Ukraine)&nbsp;</p> <p><strong>ABS 16. </strong><strong>THE CORRELATION BETWEEN THE PATHO­LOGICAL UMBILICAL ARTERY DOPPLER FINDINGS AND NEONATAL MORBIDITY OF PRETERM NEWBORNS WITH INTRAUTERINE GROWTH RESTRICTION</strong> • D. Mitrovic, A. Ristivojevic, S. Sindjic, N. Smiljanic, A. Matic, Z. Grujic, G. Ivanov, N. Stasuk (Novi Sad and Belgrade, Serbia)&nbsp;</p> <p><strong>ABS 17. </strong><strong>INTRATRACHEAL ADMINISTRATION OF SUR­FACTANT COMBINED WITH BUDESONIDE TO PREVENT BRONCHOPULMONARY DYS­PLASIA IN VERY LOW BIRTH WEIGHT PREMATURE NEWBORN</strong> • P.J. Ostia Garza, E.C. Reyes Miranda, D. Paniagua Villalobos, L. Padilla Martinez (Monterrey, Toluca, and Puebla, Mexico)&nbsp;</p> <p><strong>ABS 18. </strong><strong>CLINICAL OUTCOMES OF VERY LOW BIRTH WEIGHT INFANTS AFTER IMPLEMENTATION OF A FAMILY INTEGRATED CARE CLINICAL PATHWAY – A MATCHED CASE-CONTROL STUDY</strong> • R. Pricoco, S. Mayer-Huber, J. Paulick, F. Benstetter, M. Zeller, M. Keller (Munich, Rosenheim, and Passau, Germany)&nbsp;</p> <p><strong>ABS 19. </strong><strong>ABNORMAL RETINAL VASCULAR MOR­PHOLOGY IN PRETERM NEONATES WITH IN­TRAUTERINE GROWTH RESTRICTION</strong> •&nbsp;D. Rallis, P. Zafeiropoulos, E. Christou, M. Baltogianni, N. Dermitzaki, C. Asproudis, I. Asproudis, V. Giapros (Ioannina, Greece)&nbsp;</p> <p><strong>ABS 20. </strong><strong>ASSOCIATION BETWEEN BREASTFEEDING DURATION, MATERNAL SOCIOECONOMIC STATUS AND INFANT WEIGHT GAIN</strong> •&nbsp;J. Šarac, D. Havaš Auguštin, N. Novokmet, S. Missoni (Zagreb, Croatia)&nbsp;</p> <p><strong>ABS 21. </strong><strong>SUDDEN INFANT DEATH SYNDROME – LINK WITH MATERNAL KNOWLEDGE</strong> • L. Suciu, M. Cucerea, M. Simon (Tirgu Mures, Romania)&nbsp;</p> <p><strong>ABS 22. </strong><strong>PARENTAL PARTICIPATION IN THEIR INFANTS’ PROCEDURAL PAIN ALLEVIATION WITH NON-PHARMACOLOGICAL METHODS IN ESTONIA</strong> • A. Treiman-Kiveste, M.K. Kangasniemi, R. Kalda, T. Pölkki (Tartu, Estonia;&nbsp;Turku and Oulu, Finland)&nbsp;</p> <p><strong>ABS 23. </strong><strong>EFFECTS OF MILKING OF CUT UMBILICAL CORD IN VERY PRETERM NEONATES: A RANDOMIZED CONTROLLED TRIAL IN SOUTHERN INDIA</strong> • M. Varanattu Chellappan, D. Divakaran, N. George, S. Ayyasamy, V. Paulraj, A. Reddy Paidy, N. Johnson, P.R. Varghese, U.G. Unnikrishnan, M. Vellore, P.E.L. Lofi, K.N. Maya, D. Martin, J. James (Thrissur, India)&nbsp;</p> --- Various Authors Copyright (c) 2022 © Hygeia Press 2022-12-06 2022-12-06 12 1 e120104 e120104 10.7363/120104 Airway foreign bodies in infants younger than 6 months: a referral center experience <p class="p1"><span class="s1"><strong>Background:</strong> Although the most common age for foreign body (FB) aspiration (FBA) is considered from 1 to 4 years old, it can even happen earlier.<span class="Apple-converted-space"> </span></span></p> <p class="p1"><span class="s1"><strong>Aim:</strong> The purpose of this study is to evaluate the occurrence of FBA in 6-month infants and younger.</span></p> <p class="p1"><span class="s1"><strong>Material and methods:</strong> This study is a retrospective analysis of all the cases of FBA in infants under 6 months admitted to Namazi Hospital in Shiraz, Iran, and who underwent flexible fiberoptic bronchoscopy from September 2017 to March 2019.<span class="Apple-converted-space"> </span></span></p> <p class="p1"><span class="s1"><strong>Results:</strong> Medical records of 38 infants under 6 months of age who underwent flexible fiberoptic bronchoscopy with a diagnosis of FBA were reviewed retrospectively. 71.1% of the infants were male. History regarding prematurity was positive in 63.2% of the neonates. 55.3% had different degrees of tooth eruption. Sudden-onset cough (97.4%), noisy breathing (92.1%), and cyanotic spells (52.6%) were the 3 most common reported symptoms before hospitalization. Most (73.7%) aspirations occurred in the presence of parents or caregivers. 7.9% of the infants had normal radiographic results. Only 21.1% of the patients were diagnosed and managed within 24 hours after the aspiration. The most common aspirated FBs were organic objects.<span class="Apple-converted-space"> </span></span></p> <p class="p1"><span class="s1"><strong>Conclusion:</strong> Although FBA is more common in older children, it can also occur in infants younger than 6 months. Families, and especially physicians, should be fully informed of the possibility of aspiration at an early age, which can reduce the occurrence of FBA and its irreversible effects.</span></p> Mohammad Ashkan Moslehi Copyright (c) 2022 © Hygeia Press 2022-12-07 2022-12-07 12 1 e120103 e120103 10.7363/120103 Severe congenital thrombocytopenia and platelet dysfunction due to novel WAS gene mutation: case report <p class="p1"><span class="s1">Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia, and X-linked congenital neutropenia collectively are designated WAS-related disorders. All are attributable to pathogenic variants of the WAS protein (WASp) and present a broad spectrum of hematopoietic cellular defects that chiefly involve platelets and lymphocytes. Pathogenic mutations in the <em>WAS</em> gene (located at Xp11.22-23) are implicated, affecting 12 exons.</span></p> <p class="p1"><span class="s1">Herein, we describe a neonate with congenital thrombocytopenia and platelet dysfunction due to a novel c.1500_1504dup (p.Asp502Gly) variant of the <em>WAS</em> gene. This mutation produces a frameshift, with substitution of aspartic acid for glycine at position 502 of the protein, and causes a downstream stop-loss codon. Clinically, the infant displayed severe thrombocytopenia and thrombasthenia, in the absence of other WAS-related traits (i.e., immune deficiency, eczema). Once a multigene panel analysis was complete, conditioning and then successful hematopoietic stem-cell transplantation took place at the age of 8 months. This case highlights the importance of genetic testing in instances where other diagnostics prove inconclusive.</span></p> Darjan Kardum Borna Biljan Marijana Arambašić Copyright (c) 2022 © Hygeia Press 2022-12-07 2022-12-07 12 1 e120105 e120105 10.7363/120105