Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2021-06-03T11:13:12+02:00 JPNIM Staff Open Journal Systems <p>The <strong>Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)</strong> is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way.</p> <p>Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.</p> Laryngomalacia, GER, and sleep apnea are BRUEing – Sometimes! 2021-06-03T11:13:12+02:00 David Gozal <p>Brief resolved unexplained events (BRUE) constitute the newest nomenclature of near-miss SIDS, later on termed ALTE. These events have been putatively assigned to the sleeping state and suspected to involve airway obstruction. The current study in the Journal (Nosetti et al., 2021, <a href="" target="_blank" rel="noopener"></a>) identifies laryngomalacia and gastroesophageal reflux as being frequently associated with BRUE. The potential implications of such associations are discussed.</p> <p> </p> 2021-06-04T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press Relationship between laryngomalacia and sleep-related breathing disorders in infants with brief resolved unexplained events 2021-05-04T18:37:27+02:00 Luana Nosetti Francesca De Bernardi Eleonora Sica Patrizia Latorre Massimo Agosti Paolo Castelnuovo Giulia Cocciolo Marco Zaffanello <p class="p1"><strong>Introduction:</strong> Brief resolved unexplained events (BRUE) occur during infancy. It is characterized by one or more symptoms, including skin color change, shortness of breath and unresponsiveness. Laryngomalacia is the most frequent cause of stridor in infants and results in the collapse of the supraglottic structures during inspiration and intermittent obstruction of the upper airways. To our knowledge, the relationship between BRUE and laryngomalacia has been little investigated.</p> <p class="p1"><strong>Methods:</strong> The medical records of 448 children (age &lt; 12 months) treated for BRUE between July 2011 and March 2018 and followed up until March 2020 were retrospectively reviewed. Endoscopic evaluation was performed using a flexible fibrolaryngoscope. All patients underwent a brief polysomnography and 24-h cardiorespiratory monitoring. Cardiorespiratory and oxygen saturation monitoring was continued at home; 94% of patients underwent follow-up.</p> <p class="p1"><strong>Results:</strong> Laryngeal fiberoptic endoscopy revealed laryngomalacia in 11% of children with a clinical history of BRUE. Laryngomalacia was associated with obstructive/mixed apnea in 67%. Home cardiorespiratory monitoring showed a gradual reduction in the number of respiratory events during follow-up and complete resolution of laryngomalacia in 88% of patients.</p> <p class="p1"><strong>Conclusions:</strong> This is the first report that showed follow-up data from cases of BRUE with laryngomalacia. The improvement in laryngomalacia alone, although not complete, was sufficient to improve obstructive events.</p> 2021-06-04T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press The effect of table salt as a treatment of umbilical granuloma in neonates 2020-03-15T21:58:30+01:00 Mazin Mahmoud Fawzi <p class="p1"><span class="s1"><strong>Introduction:</strong> Umbilical granuloma is a widespread problem that may cause anguish to the parents. </span></p> <p class="p1"><span class="s1"><strong>Patients and method:</strong> A randomized controlled study was conducted on 85 neonates aged 2-4 weeks (42 males and 43 females) with a diagnosis of umbilical granuloma. They were randomly divided into 2 groups; group A included 42 patients (20 males and 22 females), and group B included 43 patients (21 males and 22 females). Parents of group A patients were instructed to use a small amount of common salt on the granuloma after cleaning it, and to cover the salt by blaster for 30 minutes to keep it in place; after that, the blaster had to be removed, and the umbilicus was cleaned with sterile cotton and water to remove the salt. The procedure was repeated for 3 days straight. Group B was treated once by applying clean dry silver nitrate sticks (concentration of 20%) on the granuloma; contact with normal skin was avoided. The procedure was performed by the researcher himself at his clinic. Statistical analysis was done by using Fisher Exact test. </span></p> <p class="p1"><span class="s1"><strong>Results:</strong> In group A, 39 (92.9%) responded to treatment by salt, while 3 (7.1%) of them did not respond. In group B, 41 (95.3%) responded to treatment by silver nitrate, while 2 (4.7%) did not respond. There was no significant difference between the two groups, with p-value = 0.676. </span></p> <p class="p1"><span class="s1"><strong>Conclusion:</strong> Umbilical granuloma can be treated with topical application of common salt; such a method can be considered a valid alternative for its effectiveness, safety, and simplicity. </span></p> 2021-06-09T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press Ischemia-modified albumin as a novel marker for diagnosis of necrotizing enterocolitis in newborn infants 2020-04-30T15:01:11+02:00 Safaa ELMeneza Asmaa Okasha Manal Abd El-Hafez Naeema Hussein <p class="p1"><strong>Background:</strong> Necrotizing enterocolitis (NEC) is the most common neonatal gastrointestinal emergency. Ischemia-modified albumin (IMA) is a marker of oxidative stress and ischemia. Its role in early diagnosis of NEC has been little investigated so far.</p> <p class="p1"><strong>Aim: </strong>The objective of our research was to study the role of serum IMA in diagnosis of NEC in newborn infants.</p> <p class="p1"><strong>Material and methods: </strong>The study was carried out on 80 neonates; 40 with NEC and 40 controls, subjected to serum IMA dosage with ELISA.</p> <p class="p1"><span class="s1"><strong>Results:</strong> There was a highly statistically significant increase in IMA in both preterm (60.59 ± 34.97 U/ml) and full-term infants with NEC (60.50 ± 29.88 U/ml) compared to their controls (11.28 ± 3.09 U/ml; 5.34 ± 1.88 U/ml). The positive predictive value of IMA in preterm and full-term with NEC was 100% and 94.74%, while the negative predictive value was 80% and 90.48%, respectively. There was a statistically significant increase in serum level of IMA in stage II NEC compared to stage I NEC as well as in non-survivor cases. Significant positive correlation between serum IMA level and duration of recovery from NEC was detected.</span></p> <p class="p1"><strong>Conclusions:</strong> IMA is a sensitive marker for diagnosis of NEC in full-term and preterm infants and can predict severity of NEC and death.</p> 2021-05-25T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press Recurrent intraparenchymal brain hemorrhage in an infant with factor XIII deficiency 2020-04-13T16:44:29+02:00 Devdeep Mukherjee Dibyendu De Satyajit Das Gopikrishna Kurasa <p class="p1">Factor XIII deficiency is an autosomal recessive disorder with an incidence of 1 in 1-5 million. On activation factor XIII stabilizes clot formation by cross-linking fibrin strands. Deficiency is characterized by severe bleeding due to impairment in clot formation. We describe a case of a child presenting with drowsiness following a trivial fall and trauma to the head. An emergency CT scan of the brain was suggestive of acute on chronic (recurrent) hemorrhage. Intraoperatively he was noted to have an intraparenchymal multiloculated cystic cavity with a thinned out cortex in the right frontal region. The child underwent right frontal craniotomy and decompression of an intracerebral hemorrhage. He was subsequently diagnosed to have factor XIII deficiency. He is presently on monthly cryoprecipitate prophylaxis with which he has not experienced a recurrence of a similar episode.</p> 2021-05-25T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press Extremely preterm infant weighing 350 g: too small to survive? 2021-05-23T18:32:18+02:00 Ieva Šliaužienė Vaida Aleksejūnė Viktorija Ambroževičiūtė Ilona Aldakauskienė Rūta Jolanta Nadišauskienė Rasa Tamelienė <p class="p1">Every year around 15 million premature neonates are born in the world, and this number is continuously increasing. The incidence of premature birth varies between 5% and 18% throughout the world. Despite advancements in medicine and technology and increased evidence-based diagnostic and treatment recommendations, prematurity is the most common cause of death among children under 5 years of age. The sequelae in the survivors of extreme prematurity are mental disability, cognitive impairment, cerebral palsy, blindness, deafness and chronic illness. Considering ethical and economic implications, neonatal survival and morbidity prognosis, resuscitation of neonates of borderline gestation differs in various countries and many international organisations do not recommend active resuscitation and treatment of newborns of up to 25 weeks of gestation. We present a case study of one of the smallest newborns in the world and the smallest newborn known to survive in Lithuania.</p> 2021-06-07T00:00:00+02:00 Copyright (c) 2021 © Hygeia Press