Nephrotoxic effects of aminoglycosides on the developing kidney
Vol. 2 No. 2 (2013), Articles
Vol. 2 No. 2 (2013)

Nephrotoxic effects of aminoglycosides on the developing kidney

Articles
https://doi.org/10.7363/020227
Published 2013-10-03
Samira Samiee-Zafarghandy
Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
Johannes N. van den Anker
Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Department of Pediatrics, Children’s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Department of Pharmacology and Physiology, Children’s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
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Keywords

aminoglycosides
nephrotoxicity
kidney
infants
fetuses
nephrogenesis

How to Cite

Samiee-Zafarghandy, S., & van den Anker, J. N. (2013). Nephrotoxic effects of aminoglycosides on the developing kidney. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM), 2(2), e020227. https://doi.org/10.7363/020227
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Abstract

Aminoglycosides are the most commonly used antibiotics in infants hospitalized in neonatal intensive care units. Despite their outstanding efficacy profile, aminoglycosides remain relatively toxic with a narrow therapeutic index and a potential to cause nephrotoxicity and/or ototoxicity. Although aminoglycoside-induced nephrotoxicity has been the subject of multiple studies, the short- and long-term effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined. In this review the currently available evidence about the effects of aminoglycosides on the developing kidney and the mechanisms involved in aminoglycoside-induced nephrotoxicity are presented.

 

Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy) · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge research

https://doi.org/10.7363/020227
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