TY - JOUR AU - Faa, Gavino AU - Fanos, Vassilios AU - Puddu, Melania AU - Reali, Alessandra AU - Dessì, Angelica AU - Pichiri, Giuseppina AU - Gerosa, Clara AU - Fanni, Daniela PY - 2016/07/22 Y2 - 2024/03/29 TI - Breast milk stem cells: four questions looking for an answer JF - Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) JA - J Pediatr Neonat Individual Med VL - 5 IS - 2 SE - DO - 10.7363/050203 UR - https://jpnim.com/index.php/jpnim/article/view/050203 SP - e050203 AB - <p>The finding of stem/progenitor cells in the maternal milk and the discovery of their multilineage potential, associated with some evidence regarding the ability of maternal cells to cross the gastrointestinal barrier and integrate into the organs of the breastfed neonate, has opened an intriguing debate, regarding the strict relationship between mother and son in the postnatal period. In particular, thanks to the discovery of the presence in high quantities of mammary stem cells, a new vision of maternal milk is emerging, in which breastfeeding appears as an unique occasion for reinforcing the physiological development of the newborn, putting all the formulas at a different level of relevance for the neonate. In this contribution the authors try to give an answer to the following 4 questions:</p><ol><li>is there heterogeneity and a hierarchy among breast milk stem cells?</li><li>can stem cells present in breast milk enter into the newborn organism?</li><li>can breast milk stem cells integrate in the neonatal organs and differentiate toward different tissues, including neurons and neuroglia?</li><li>could metabolomics be useful for the study of stem cells in the human milk?</li></ol><p> </p><p><strong>Proceedings of the 2<sup>nd</sup> International Course on Perinatal Pathology </strong><strong>(part of the 11<sup>th</sup> International Workshop on Neonatology · October 26<sup>th</sup>-31<sup>st</sup>, 2015) · Cagliari (Italy) · October 31<sup>st</sup>, 2015 · <em>Stem cells: present and future </em></strong><br /><strong>Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano</strong></p> ER -