@article{Alizadeh Taheri_Rostami_Eftekhari_Danesh_2021, place={Quartu Sant’Elena (CA, Italy)}, title={Synbiotic therapy in infantile colic resistant to conservative therapy: a clinical trial}, volume={10}, url={https://jpnim.com/index.php/jpnim/article/view/e100128}, DOI={10.7363/100128}, abstractNote={<p class="p1"><span class="s1"><strong>Background: </strong>Infantile colic is a disturbing problem for parents. The Rome IV criteria are the last modality for the diagnosis of colic. Available medications have variable effects on the treatment of colic. However, no definite treatment has been identified yet.</span></p> <p class="p1"><span class="s1"><strong>Aims: </strong>To our knowledge, few clinical trials have compared the efficacy of synbiotics in infantile colic, so the present study was conducted. </span></p> <p class="p1"><span class="s1"><strong>Material and methods:</strong> This study was performed on 120 infants (51.66% boys; mean age: 42.09 ± 21.14 days; mean birth weight: 3,155 ± 420 g) with the diagnosis of infantile colic resistant to conservative therapy. The infants were randomly divided into groups A and B. A synbiotic containing <em>B. infantis</em>, <em>L. reuteri</em>, <em>L. rhamnosus</em>, and fructooligosaccharides (FOS) (PediLact® [Zist-Takhmir Co., Tehran, Iran] drop) was administered to group A, while group B received a synbiotic containing <em>B. lactis</em> and FOS (BBCare® [Zist-Takhmir Co., Tehran, Iran] drop). The primary outcome was the response rate to each synbiotic, and the secondary outcome was the complications of each synbiotic. </span></p> <p class="p1"><span class="s1"><strong>Results: </strong>The response rate to both synbiotics was significant after 1 week of intervention (1.97 ± 0.91 [44.95%] versus 1.64 ± 0.77 [54.23%], p = 0.000). Both groups showed a significant response rate to each synbiotic after 1 month of intervention too (1.19 ± 0.84 [63.48%] versus 0.70 ± 0.48 [79.65%], p = 0.000). The response rate was significantly higher in group B compared to group A after 1 week (54.23% versus 44.95%) and after 1 month (79.65% versus 63.48%) of intervention. Neither synbiotic was associated with adverse effects.</span></p> <p class="p1"><span class="s1"><strong>Conclusion: </strong>The present study showed that both synbiotics were effective in the treatment of infantile colic. However, the synbiotic containing <em>B. lactis</em> was significantly more effective than the synbiotic containing <em>B. infantis</em>, <em>L. reuteri</em>, and <em>L. rhamnosus</em> in infantile colic. </span></p>}, number={1}, journal={Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)}, author={Alizadeh Taheri, Peymaneh and Rostami, Shima and Eftekhari, Kambiz and Danesh, Sedigheh}, year={2021}, month={Feb.}, pages={e100128} }